Microbiological quality of soils

Genomics enables the development of a new form of agriculture, adopting a more holistic approach that focuses on the interactions between plants and micro-organisms.
It specifically allows us to highlight the interactions that soil bacteria, yeasts and fungi can have with different crops, whether they are annual or perennial.
GenoScreen has established its expertise in this field by contributing, in a pioneering position, in national projects such as BIMM-SOL and GenoSol, which focused on the microbiological quality of soils.

GenoScreen’s offer to understand the microbiological component of soils

GenoScreen helps you to identify the microbiological composition of soils, reveal their properties and act on them, either by using inputs or by modifying your farming practices. Our services and solutions include:

• Study of the microbiological component of soils: taxonomy of the microorganisms presents and measurement of the fungal/bacterial balance
• Identification and characterisation of bioinputs (biostimulants and biopesticides) along with studying their impact on soil microbiological quality
• Analysis of the microbiological composition of soils at different times and under various conditions (crops, ploughing, inputs, climate, etc.)
• Support for research, particularly in the development of new inputs

Soil study techniques and methods

Our analysis solutions are based on the latest techniques available (Illumina, PacBio and ONT sequencers), and include a wide range of methods:

• NGS (Next-Generation Sequencing): Genome studies using the latest sequencing technologies 
• Molecular metabarcoding: Taxonomic study of microbial populations
• Metagenomics or environmental genomics: Study of the genetic content of samples within an ecosystem to reveal both taxonomy and putative functions
• Metatranscriptomics: Study of all active microbial genes and pathways in a sample (the transcriptome)
• qPCR (Quantitative Polymerase Chain Reaction): Quantification of microorganisms of interest present in a sample

These analyses, along with the conclusions and solutions they provide, require the ability to access repositories of characterised genomic data. Such data repositories can be found in databases of varying degrees of specialisation and documentation. In this regard, our expertise led us to select the best databases and to develop our own, as well as the ability to utilise them effectively.

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Genomics for Cosmetics

Genomics, and above all metagenomics, constitute the sharpest method for studying interaction between skin and its microbiota, and analysis the entirety of the microorganism communities present on the epidermis.

Advances in science allow us to explore the genes and molecular interactions that influence the health and appearance of our skin.

Explore the genomic solutions that are transforming the way we understand and treat dermatological needs, opening up new innovations for Beauty Care and strong assets for new products development.

Applications of genomics for skincare

Genomics provides breakthrough innovation and technological inputs in the cosmetics and skin care sector :

Microbiome

• Skin microbiome impact studies of dermocosmetics product or active ingredient
• Clinical studies in dermatology to measure treatments effects on skin diseases
• Analysis of dysbiosis in the microbiota of interest
• Virulent strains genomic characterization of certain bacterial or fungal species of interest 

Science added-value

• Claim substantiation and scientific added-value for new dermocosmetics products, formulations, active ingredients.
• Prebiotics, probiotics and postbiotics evaluation to assess their efficiency
• Nutricosmetics and Cosmeceuticals assay through gut-skin axis study

Industry

• Optimized production processes for cosmetic ingredients (biotechnology and fermenters)
• Quality control, microbiological monitoring and contaminants detection in Cosmetics production processes

Our analytical solutions for dermocosmetics

As a true scientific partner, GenoScreen provides the beauty and skin care sector with tailor-made solutions and high-performance tools that boost innovation :

• Skin Microbiota :
  • GenoBiome Skin, our all-in-one offer for analysing cutaneous microorganism communities
  • Microbiome friendly testing
  • Metagenomics with several adaptable technologies to shape your own projects : targeted metagenomics 16S (bacteria), 18S/ITS (fungi) in short read and long read, shotgun metagenomics from skin swab samples.

• Strain-specific solutions :
  • Genomic tools for identifying, sequencing, annotating and comparing microbial genomes.
  • Genotyping strains of interest (virulence detection)
  • Bacterial/fungal genes differential expression under varying conditions (with or without application of an active ingredient, for example), using Transcriptomics (RNA-Seq)
  • Microorganism strains quantification through qPCR approach

• Expertise and know-how :

• Bioinformatics : customized pipeline developed by GenoScreen, interactive and comprehensive reports
• Support from experts : from experimental protocol design to results interpretation, our team of microbiologists will provide you answers to you initial biological questions.
• Skincare claims validation and Regulatory dossiers fulfillment.

GenoScreen’s commitment : To provide an exceptional customer experience for your sequencing needs. 

Examples of GenoScreen involvement in R&D projects for Skin Care:

Callejon, S., Giraud, F., Larue, F., Buisson, A., Matéos, L., Grare, L., Guyoux, A., Perrier, E., Ardiet, N., & Trompezinski, S. (2020). Respect of Skin Microbiome with Different Types of Leave-on Skincare Products, an Ecobiological Approach. Preprints. https://doi.org/10.20944/preprints202005.0500.v1

Bianchi, P., Theunis, J., Casas, C., Villeneuve, C., Patrizi, A., Phulpin, C., Bacquey, A., Redoulès, D., Mengeaud, V., & Schmitt, A. M. (2016). Effects of a New Emollient-Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis. Pediatric dermatology, 33(2), 165–171. https://doi.org/10.1111/pde.12786

Blanchet-Réthoré S, Bourdès V, Mercenier A, Haddar CH, Verhoeven PO, Andres P. Effect of a lotion containing the heat-treated probiotic strain Lactobacillus johnsonii NCC 533 on Staphylococcus aureus colonization in atopic dermatitis. Clin Cosmet Investig Dermatol. 2017;10:249-257. https://doi.org/10.2147/CCID.S135529

Hilaire, P., Landemaine, L., Contreras, S., Blanquart-Goudezeune, H., Siguier, P., Cornet, F., Chiapello, H., Loux, V., Clavaud, C., & Morand, S. C. (2021). Complete Genome Sequence of Staphylococcus epidermidis PH1-28, Isolated from the Forehead of a Hyperseborrheic Donor. Microbiology resource announcements, 10(9), e00165-21. https://doi.org/10.1128/MRA.00165-21

Landemaine, L., Da Costa, G., Fissier, E., Francis, C., Morand, S., Verbeke, J., Michel, M. L., Briandet, R., Sokol, H., Gueniche, A., Bernard, D., Chatel, J. M., Aguilar, L., Langella, P., Clavaud, C., & Richard, M. L. (2023). Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation. Frontiers in immunology, 14, 1098160. https://doi.org/10.3389/fimmu.2023.1098160

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GenoScreen provides biotech companies with access to high-level, flexible, agile genomics services that match perfectly to their needs in innovative R&D groups.

Access to cutting-edge genomics facilities

For start-ups, GenoScreen provides guaranteed access to cutting-edge technical facilities that have been designed for research and innovation in genomics.

Our facilities were equipped to address the demands of the pharmaceutical and agrifood sectors, and are structured to deliver irreproachable, high-quality results.

Our services cover the full range of needs in genomics and metagenomics :

• Sanger sequencing and NGS
• Targeted sequencing
• Genotyping
• Metagenomics
• Metatranscriptomics

Your partner in innovation

As specialists in innovation, GenoScreen’s scientific staff can get involved in high-level collaborative projects and add their valuable experience to your research efforts. Our organizational structure ensures full confidentiality and the protection of your intellectual property rights.

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Ever since its foundation, GenoScreen has worked with groups from academia, research centers and public-sector healthcare institutions. 

Our team’s expertise and experience have always met the quality requirements of these complex projects.

GenoScreen works alongside academic groups in many public-sector and mixed private-/public-sector research projects worldwide. GenoScreen provides to these market players a high-level technological platform enabling the completion of the most complex analyses and a focus on customer care. Beyond these criteria, GenoScreen can respond effectively to time constraints thanks to its flexibility and its staff effectiveness.”

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Increasing agricultural production, improving the value and nutritional qualities of food, ensuring food safety and reducing their environmental impact: the agricultural and agrifood markets are facing major technological challenges worldwide. Genomics is used to characterize living organisms and it enables researchers to analyze and understand many of the processes linked to food production: the quality and quantity of raw materials, the genetic evolution of species, soil quality for crops, feed quality for livestock, etc.

Applications

Genomics now provides innovative, relevant solutions to suit the needs of this market:

• Developing crop resistance to diseases, parasites, extreme weather conditions...
• Improving the nutritive qualities of crops.
• Limiting the health impact of biopesticides.
• Improving the digestibility of animal feeding products.
• Creating traceability tools for food, crop and livestock production.

GenoScreen - Services provided

GenoScreen has developed specific genomics and bioinformatics services for the animal husbandry, nutrition and agrifood sectors:

• The characterization and monitoring of microbial communities in fermented products (yogurt, wine, cheese, etc.).
• The identification, characterization, detection and quantification of probiotic finished products.
• The monitoring of soil quality (particular the rhizosphere/rhizobium).
• The evaluation of impacts on crop yields.
• Determination of a food product impact on the intestinal microbiota

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Genomics provides new ways of understanding, characterizing and protecting the environment by measuring, for example, biodiversity and genetic evolution. It notably helps researchers to understand how microorganisms, animals and plants interact with their environment.

Applications

Genomic analyses provide new environmental solutions that maintain profitability while protecting natural resources:

• Developing microbiological tools for the management, monitoring and remediation of polluted sites.
• Providing more effective, ecological control methods or biological treatments.
• Predicting the appearance of infestations and the dispersal of insect pests.
• Monitoring the impact of construction work and urban development on biodiversity.
• Monitoring, conserving and adding value to the natural genetic diversity of species.

GenoScreen - Services provided

GenoScreen has developed specific solutions for the environmental sector:

• GenoSNP^® for polymomorphisms identification and genotyping (SNP-like genetic variants).
• Population biology tools (GenoSat^®).
• Microbial ecology analyses (MetaBiote^®/ WHORMSS^®).
• The quantification and monitoring of specific genes and species.

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Genomics is now an essential technology in healthcare research. As such, GenoScreen is a preferred partner that adds value through the quality of its analyses, its metagenomics skills and its expertise in microbiology.

Infectious diseases

Metagenomics

Metagenomics can notably be used to study the intestinal microbiota, which has various impacts on human health. These analyses are opening up new diagnostic and therapeutic approaches in the management of obesity, diabetes and chronic inflammatory bowel diseases, amongst others.

The Metabiote^® and WHORMSS^® solutions developed by GenoScreen are comprehensive, ready-to-go solutions for all metagenomics studies.

Personalized medicine and biomarkers

GenoScreen’s genomics services can be used to discover biomarkers for application in diagnostics and personalized medicine:

• The identification and analysis of molecular biomarkers involved in mechanisms of interest.
• The development of targeted treatment strategies.
• The development of genomic profiles for implementing personalized medicine.

Oncology

Oncology research can draw upon whole-genome and whole-exome sequencing for the characterization of specific mutations or other biomarkers. Genomic analysis can also be used in clinical trials.

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