Skin Care

Genomics, and above all metagenomics, constitute the sharpest method for studying interaction between skin and its microbiota, and analysis the entirety of the microorganism communities present on the epidermis.

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Skincare creams and cosmetic products representing metagenomic applications in skin microbiome analysis and dermocosmetic innovation

Genomics for skincare innovation & dermatological research

Advances in science allow us to explore the genes and molecular interactions that influence the health and appearance of our skin. Explore the genomic solutions that are transforming the way we understand and treat dermatological needs, opening up new innovations for Beauty Care and strong assets for new products development.

Applications of genomics for skincare

Genomics provides breakthrough innovation and technological inputs in the cosmetics and skin care sector :

Microbiome

Skin microbiome impact studies of dermocosmetics product or active ingredient

Clinical studies in dermatology to measure treatments effects on skin diseases

Analysis of dysbiosis in the microbiota of interest

Virulent strains genomic characterization of certain bacterial or fungal species of interest

Science added-value

Claim substantiation and scientific added-value for new dermocosmetics products, formulations, active ingredients

Prebiotics, probiotics and postbiotics evaluation to assess their efficiency

Nutricosmetics and Cosmeceuticals assay through gut-skin axis study

Industry

Optimized production processes for cosmetic ingredients (biotechnology and fermenters)

Quality control, microbiological monitoring and contaminants detection in Cosmetics production processes

Our analytical solutions for dermocosmetics

GenoScreen, scientific partner for the beauty and skincare sector

Skin microbiota

GenoBiome®

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Our all-in-one offer for analysing cutaneous microorganism communities

Skin microbiome analysis

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For microbiome friendly skin-careing

Metagenomics

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Targeted metagenomics 16S (bacteria), 18S/ITS (fungi) in short read & long read, shotgun metagenomics

Strain-specific solutions

Genotyping

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Genotyping strains of interest
(virulence detection)

RNA-Seq

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Bacterial/fungal genes differential expression under varying conditions (with or without application of an active ingredient, for example)

qPCR

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Microorganism strains
quantification

Expertise & know-how

Bioinformatics

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Customized pipeline developed by GenoScreen, interactive and comprehensive reports

Regulatory compliance

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Skincare claims validation and regulatory dossiers fulfillment

Redefine Service

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Support from experts : from experimental protocol design to results interpretation, our team of microbiologists will provide you answers to you initial biological questions

Examples of GenoScreen involvement in R&D projects for Skin Care

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Microbiome Modulation in Acne Patients and Clinical Correlations

https://doi.org/10.3390/life14060688

Ionescu M-A, Tatu AL, Busila C, Axente ER, Badalato N, Feuilloley MGJ, Asquier E, Martínez JD, Lefeuvre L. Microbiome Modulation in Acne Patients and Clinical Correlations. Life. 2024; 14(6):688.

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Respect of Skin Microbiome with Different Types of LeavE-on Skincare Products, an Ecobiological Approach

https://doi.org/10.20944/preprints202005.0500.v1

Callejon, S., Giraud, F., Larue, F., Buisson, A., Matéos, L., Grare, L., Guyoux, A., Perrier, E., Ardiet, N., & Trompezinski, S. (2020). Respect of Skin Microbiome with Different Types of LeavE-on Skincare Products, an Ecobiological Approach. Preprints.

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Effects of a New Emollient-Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis

https://doi.org/10.1111/pde.12786

Bianchi, P., Theunis, J., Casas, C., Villeneuve, C., Patrizi, A., Phulpin, C., Bacquey, A., Redoulès, D., Mengeaud, V., & Schmitt, A. M. (2016). Effects of a New Emollient-Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis. Pediatric dermatology, 33(2), 165–171.

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Complete Genome Sequence of Staphylococcus epidermidis PH1-28, Isolated from the Forehead of a Hyperseborrheic Donor

https://doi.org/10.1128/MRA.00165-21

Hilaire, P., Landemaine, L., Contreras, S., Blanquart-Goudezeune, H., Siguier, P., Cornet, F., Chiapello, H., Loux, V., Clavaud, C., & Morand, S. C. (2021). Complete Genome Sequence of Staphylococcus epidermidis PH1-28, Isolated from the Forehead of a Hyperseborrheic Donor. Microbiology resource announcements, 10(9), e00165-21.

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Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation

https://doi.org/10.3389/fimmu.2023.1098160

Landemaine, L., Da Costa, G., Fissier, E., Francis, C., Morand, S., Verbeke, J., Michel, M. L., Briandet, R., Sokol, H., Gueniche, A., Bernard, D., Chatel, J. M., Aguilar, L., Langella, P., Clavaud, C., & Richard, M. L. (2023). Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation. Frontiers in immunology, 14, 1098160.