A new study evaluated the impact of probiotic yeast S. boulardii CNCM I-745 on lipid profile in a hypercholesterolemia model in hamsters, combining analyses of intestinal microbial communities carried out via our Metabiote solutions.
Hamsters were fed with a high-cholesterol diet (0.3% cholesterol) only while another group received an additional 3g/kg of S. boulardii CNCM I-745 daily. Treatment with S. boulardii CNCM I-745 significantly reduced plasmatic cholesterolemia and increased fecal cholesterol. It also significantly altered the composition of the intestinal microbiota. The analysis of the intestinal microbiota was performed by GenoScreen, from DNA extraction from the faeces to taxonomic and diversity analysis.
The Metabiote solution used for this study is a standardized protocol, developed by GenoScreen, that guarantees the repeatability and reproducibility of experimental results. Compliant with GcLP standards, the Metabiote analysis solution allows statistical comparisons of microbial composition and diversity on sample cohorts with limited methodological bias.