One of the biggest challenges in genomics is being able to connect a phenotype to the available genetic information. Mutation detection and whole-genome comparison techniques can go beyond the simple observation of a genome, in order to make an evolution in your researches.

Applications

Whole-genome comparisons and mutation detection are deployed to identify genes and mutations of interest with regard to a molecular or cellular phenotype (antibiotic resistance, enzyme activity, etc.).

These two approaches make it possible to set up new genomic selection criteria in agriculture, identify drug targets, select specific strains, and discover novel biomarkers, for example.

GenoScreen - Services provided

Mutations of interest (SNPs or indels) are detected by comparing similar sequences (e.g. genomes/transcriptomes from two members of the same species).

This comparison involves mapping the sequences on a reference sequence. The segment of the reference genome covered must be similar for the two compared sequences.

The GenoScreen's assets

  • Specific processing of sequencing information in order to improve their quality and clarity.
  • Detailed annotation of genes and sequences of interest.
  • Precise algorithms for alignment with reference sequences.
  • Whole-genome comparisons.

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