{"id":509,"date":"2020-11-02T12:02:41","date_gmt":"2020-11-02T11:02:41","guid":{"rendered":"https:\/\/www.genoscreen.fr\/premiere-evaluation-complete-deeplex-myc-tb\/"},"modified":"2020-11-02T12:02:41","modified_gmt":"2020-11-02T11:02:41","slug":"premiere-evaluation-complete-deeplex-myc-tb","status":"publish","type":"post","link":"https:\/\/www.genoscreen.fr\/fr\/actualites\/premiere-evaluation-complete-deeplex-myc-tb\/","title":{"rendered":"Publication de la premi\u00e8re \u00e9valuation compl\u00e8te des performances du test \u00abDeeplex\u00ae Myc-TB\u00bb de pr\u00e9diction des antibior\u00e9sistances de la tuberculose"},"content":{"rendered":"

COMMUNIQUE DE PRESSE – Le test innovant de pr\u00e9diction des antibior\u00e9sistances de la tuberculose, Deeplex\u00ae Myc-TB a \u00e9t\u00e9 \u00e9valu\u00e9 par une \u00e9quipe de recherche internationale. En testant plus de 5\u2009600 \u00e9chantillons d\u2019origine et de nature diverses, cette \u00e9tude mesure pour la premi\u00e8re fois la sensibilit\u00e9, la sp\u00e9cificit\u00e9 et la limite de d\u00e9tection de ce test.<\/p>\n

<\/p>\n

Avec 10 millions de nouveaux cas par an, et 1,4 million de morts en 20181<\/sup>, la tuberculose reste la maladie infectieuse bact\u00e9rienne la plus mortelle au monde. L’\u00e9mergence et la diss\u00e9mination de souches mycobact\u00e9riennes multir\u00e9sistantes aux antibiotiques (\u00e0 l\u2019origine de pr\u00e8s de 400\u2009000 nouveaux cas en 2018) est un probl\u00e8me mondial de sant\u00e9 publique qui complexifie la lutte contre la tuberculose. <\/p>\n

Le test Deeplex\u00ae Myc-TB permet, gr\u00e2ce \u00e0 son ing\u00e9nierie innovante par s\u00e9quen\u00e7age en profondeur, d\u2019\u00e9tudier simultan\u00e9ment les r\u00e9sistances \u00e0 13 classes de mol\u00e9cules antibiotiques2<\/sup> incluant les antituberculeux de 1re et de 2de intention, dont de nouvelles mol\u00e9cules. Ce test est bas\u00e9 sur l\u2019amplification et le s\u00e9quen\u00e7age cibl\u00e9 de plus de 20 r\u00e9gions g\u00e9n\u00e9tiques. Il conf\u00e8re l\u2019avantage de permettre un diagnostic complet du profil d\u2019antibior\u00e9sistance et du g\u00e9notype de la bact\u00e9rie, \u00e0 partir d\u2019un \u00e9chantillon clinique, sans \u00e9tape de culture pr\u00e9alable.<\/p>\n

L\u2019\u00e9tude publi\u00e9e dans la revue m\u00e9dico-scientifique \u00ab the European Respiratory journal<\/em> \u00bb3<\/sup> est la premi\u00e8re \u00e0 \u00e9valuer exhaustivement la sp\u00e9cificit\u00e9, la sensibilit\u00e9 et la limite de d\u00e9tection de ce test, sur base d\u2019un large panel de plus de 4\u2009000 souches et 1\u2009600 \u00e9chantillons cliniques. Pour r\u00e9aliser cette \u00e9valuation, l\u2019\u00e9quipe de GenoScreen a analys\u00e9 les donn\u00e9es d\u2019antibior\u00e9sistance obtenues avec Deeplex\u00ae Myc-TB, en les comparant \u00e0 celles de tests de r\u00e9f\u00e9rence actuellement en vigueur (tests ph\u00e9notypiques et\/ou analyses du g\u00e9nome complet (WGS), r\u00e9alis\u00e9s apr\u00e8s culture), que des \u00e9quipes belges (Institute of Tropical Medicine -Anvers, Sciensano, – Bruxelles) et italienne (Institut San Raffaelle – Milan) ont obtenues.<\/p>\n

Lire la suite<\/a><\/p>\n

1<\/sup> OMS. Global tuberculosis report 2019. https:\/\/www.who.int\/tb\/publications\/global_report\/en\/<\/a>
2<\/sup> Mol\u00e9cules de 1re intention (rifampicine, isoniazide, pyrazinamide, ethambutol)\u2009; mol\u00e9cules de 2de intention : \u2013 fluoroquinolones (telles que la levofloxacine, moxifloxacine et ciprofloxacine), aminoglycosides (kanamycine, amikacine, capreomycine, streptomycine), \u2013 \u00e9thionamide, \u2013 clofazimine\u2009, et de nouvelles mol\u00e9cules antibiotiques (b\u00e9daquiline, lin\u00e9zolide).
3<\/sup> Jouet A, Gaudin C, Badalato N, et al. Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs. Eur Respir J 2020; in press (https:\/\/doi.org\/10.1183\/13993003.02338-2020<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"

COMMUNIQUE DE PRESSE – Le test innovant de pr\u00e9diction des antibior\u00e9sistances de la tuberculose, Deeplex\u00ae Myc-TB a \u00e9t\u00e9 \u00e9valu\u00e9 par une \u00e9quipe de recherche internationale. En testant plus de 5\u2009600 \u00e9chantillons d\u2019origine et de nature diverses, cette \u00e9tude mesure pour la premi\u00e8re fois la sensibilit\u00e9, la sp\u00e9cificit\u00e9 et la limite de d\u00e9tection de ce test.<\/p>\n","protected":false},"author":1,"featured_media":1108,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-509","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites"],"yoast_head":"\nPublication de la premi\u00e8re \u00e9valuation compl\u00e8te des performances du test \u00abDeeplex\u00ae Myc-TB\u00bb de pr\u00e9diction des antibior\u00e9sistances de la tuberculose - GenoScreen<\/title>\n<meta name=\"description\" content=\"\u00a0Le test innovant de pr\u00e9diction des antibior\u00e9sistances de la tuberculose Deeplex\u00ae Myc-TB a \u00e9t\u00e9 \u00e9valu\u00e9 par une \u00e9quipe de recherche internationale. 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