{"id":853,"date":"2025-09-30T16:49:05","date_gmt":"2025-09-30T14:49:05","guid":{"rendered":"https:\/\/www.genoscreen.fr\/how-to-prove-the-efficacy-of-a-probiotic-or-postbiotic-using-genomics\/"},"modified":"2026-06-07T15:44:30","modified_gmt":"2026-06-07T13:44:30","slug":"how-to-prove-the-efficacy-of-a-probiotic-or-postbiotic-using-genomics","status":"publish","type":"post","link":"https:\/\/www.genoscreen.fr\/en\/news\/how-to-prove-the-efficacy-of-a-probiotic-or-postbiotic-using-genomics\/","title":{"rendered":"How to prove the efficacy of a probiotic or postbiotic using genomics?"},"content":{"rendered":"

Biotics<\/strong> \u2014 whether prebiotics, probiotics, or postbiotics \u2014 are at the core of nutritional and therapeutic strategies<\/strong> aimed at preserving or restoring gut microbiota balance. However, with increasing regulatory requirements (EFSA<\/a>, FDA) and growing market competition, it is crucial to demonstrate their efficacy through robust scientific evidence.<\/p>\n

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Why is microbiota analysis essential for developing a biotic?<\/h3>\n

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A biotic\u2019s value lies in its ability to interact with both the microbiota and the host<\/strong>. Studying the microbiota helps to:<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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– Identify potential probiotic strains<\/strong> (isolated from healthy microbiota)<\/p>\n

– Validate target effects<\/strong> (restoration of diversity, activation of beneficial metabolic functions)<\/p>\n

– Provide scientific evidence supporting product benefits<\/strong>, aligned with regulatory expectations<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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How to scientifically demonstrate the efficacy of a probiotic?<\/h3>\n

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Probiotic efficacy can be assessed at two levels:<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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– Clinically<\/strong> , through measurable outcomes in subjects (e.g., digestion, immunity, inflammation, etc)<\/p>\n

– Biologically<\/strong>, through microbiota analyses showing structural or functional changes after administration<\/p>\n

Targeted or whole-metagenome sequencing<\/strong> (First Res & Full Reveal<\/a>) approaches help demonstrate these modifications in in vitro, in vivo, or clinical studies.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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How to measure a biotic’s impact on gut microbiota?<\/h3>\n

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The impact of a biotic can be evaluated by analyzing:<\/p>\n

– The microbial species composition<\/strong> (microbiota structure)<\/p>\n

– The associated genes and biological functions<\/strong> (e.g., SCFA production, inflammation regulation)<\/p>\n

These insights are obtained using metagenomics<\/strong>, for species and encoded functions and metatranscriptomic<\/strong>, for functions actually expressed in the microbiome (Activ’Reveal<\/a>).<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Can a specific probiotic strain be tracked in a complex ecosystem?<\/h3>\n

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Yes with strain-specific tools such as qPCR<\/strong> (iQuant<\/a>), it is possible to:<\/p>\n

– Detect a target strain<\/strong> within a complex microbial community<\/p>\n

– Quantify<\/strong> its relative abundance<\/p>\n

– Distinguish between live and dead cells<\/strong> (using PMA treatment)<\/p>\n

This is essential for verifying probiotic persistence in the microbiota and for quality control in finished products.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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<\/div>\n","protected":false},"excerpt":{"rendered":"

Biotics \u2014 whether prebiotics, probiotics, or postbiotics \u2014 are at the core of nutritional and therapeutic strategies aimed at preserving or restoring gut microbiota balance. However, with increasing regulatory requirements (EFSA, FDA) and growing market competition, it is crucial to demonstrate their efficacy through robust scientific evidence.<\/p>\n","protected":false},"author":1,"featured_media":1383,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[167],"tags":[],"class_list":["post-853","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nHow to prove the efficacy of a probiotic or postbiotic using genomics? - GenoScreen<\/title>\n<meta name=\"description\" content=\"Discover how GenoScreen uses genomics and metagenomics to scientifically prove the efficacy of probiotics and postbiotics. 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