{"id":468,"date":"2019-12-10T14:04:51","date_gmt":"2019-12-10T13:04:51","guid":{"rendered":"https:\/\/www.genoscreen.fr\/miru-vntr-eng\/"},"modified":"2026-07-13T19:28:58","modified_gmt":"2026-07-13T17:28:58","slug":"miru-vntr","status":"publish","type":"page","link":"https:\/\/www.genoscreen.fr\/en\/genomic-services\/miru-vntr\/","title":{"rendered":"MIRU-VNTR – Mycobacterium Tuberculosis typing solutions"},"content":{"rendered":"\n

GenoScreen<\/a>‘s MIRU-VNTR<\/strong> typing solution is used by many healthcare centers, CNR and research teams worldwide, both as kits and as service.<\/p>\n\n

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MIRU-VNTR, a global reference<\/h2>\n\n

The MIRU-VNTR typing<\/h3>\n\n

The MIRU-VNTR (Mycobacterial Identification Repetitiv Unit-VNTR)<\/strong> analysis is an MLVA <\/strong>(Multiple Loci VNTR Analysis) analysis scheme specific to Mycobacterium tuberculosis<\/em><\/strong>. This is used in the genotyping of strains by numbering copies of VNTR present in 24 identified loci. The targeted VNTR loci<\/strong> are amplified by PCR with a set of primers specific for the flanking regions of each locus. The fragments thus obtained are processed by capillary electrophoresis. This method is the world standard for Mycobacterium tuberculosis typing<\/em><\/strong>, adopted by American and European CDCs and reference centers in more than 30 countries. <\/p>\n\n

GenoScreen’s MIRU-VNTR solution became the international standard reference for the MIRU-VNTR method (tests performed by RIVM 3<\/a>, 4<\/a><\/sup>). It comes in a range of exclusive kits<\/strong> adapted to each step of the MIRU analysis (Calibration, validation and typing). This complete solution is optimized to deliver the best possible results<\/strong> with a standardized approach<\/strong>, while maintaining high reproducibility<\/strong>. <\/p>\n\n

Learn more about our MIRU-VNTR kits<\/a><\/p>\n\n

MIRU-VNTR Hypervariable, a scheme adapted to the strains of the Beijing lineage<\/h3>\n\n

M. tuberculosis<\/em> strains identified as belonging to the so-called “Beijing” lineage<\/strong> cannot be distinguished by using the standard 24 loci. The sub-lineages in this family are identified by a MIRU analysis using a set of 4 additional hypervariables<\/strong> VNTR loci 1<\/a>, 2<\/a><\/sup>. The MIRU-VNTR Hypervariable kit from GenoScreen enables this additional targeted analysis to be carried out. <\/p>\n\n

GenoScreen’s MIRU-VNTR solution is also available in a range specially designed for this complementary targeted analysis. The MIRU-VNTR Hypervariable kits (calibration, validation and typing) allow this specific typing<\/strong>, while benefiting from the same results quality and reproducibility as our MIRU-VNTR solution. <\/p>\n\n

Learn more about our MIRU-VNTR Hypervariable kits<\/a><\/p>\n\n

GenoScreen’s expertise<\/h2>\n\n

With its cutting-edge technological expertise<\/strong>, GenoScreen is currently the leader worldwide in the genotyping and tracing of the Mycobacterium tuberculosis<\/em> complex strains<\/strong>, the agent responsible for tuberculosis<\/strong>.<\/p>\n\n

As kit or service packages, our solutions can be adapted to all issues:<\/p>\n\n