Current project

HUMAN HEALTH

Neuro-degeneratives diseases


DETECTION KIT FOR ALZHEIMER'S DISEASE AND RELATED DISORDERS

Purpose: the aim of this project is to develop an ELISA kit to detect and quantify the OTC protein in the cerebrospinal liquid, in order to integrate it in clinical trials and to develop a diagnostic test for Alzheimer's disease.

Partners: INSERM U1167 (Unit of Epidemiology and Public Health – University of Lille 2 Law & Health)

Funding: Cofunding FUI / GENOSCREEN

Program: Originally : FUI (9th call for proposals) "MEDIALZ" project (Diagnostic and therapeutic care of Alzheimer's disease and related disorders)

MEDIALZ partners

  • Inserm team U744-3 « Research of molecular determinants in neurodegeneratives disorders» from laboratory of « Public health and molecular epidemiology of age-related diseases » (U 744 - Pasteur Institute of Lille, Inserm and University Lille North of France, UDSL)
  • Inserm team U837-1 «Alzheimer & Tauopathies », from Resarch Center Jean-Pierre AUBERT (U 837 - CHU Lille and University Lille North of France)
  • The Memory Resources & Research Centre of Lille-Bailleul (CMRR) (University Lille North of France, UDSL, CHU Lille), associated with EA «Alzheimer and vascular pathologies »


Tumorous diseases


PROFILING OF INTESTINAL MICROBIOTA FOR THE DIAGNOSIS OF COLORECTAL CANCER

Modulation of bacterial community in colorectal cancer : Identification of microbial markers for early diagnostic

Partners 

  • University Paris-Est Créteil Val de Marne (UPEC) / Laboratory for the study of colon cancer by microbial and molecular methods (EC2M3)
  • Henri Mondor hospital

Funding: Cofunding GENOSCREEN / UPEC


Infectious diseases

Parasitic infections


CONSTITUTIONAL RESISTANCE TO MALARIA

Identification of genetic mutations which involve a constitutional resistance to malaria

Partners:

  • IRD UMR 216 (Paris Descartes University) Team « Infectious diseases and immunity : genetic susceptibility and selection pression  »
  • Paris Descartes University

Funding: Cofunding GENOSCREEN / IRD Paris Descartes


Viral Infections


FLU-MICROBIOT

Role of microbiota and gastrointestinal/pulmonary axis in the respiratory diseases due to the flu

Partners:

  • Pasteur Institute of Lille, CNRS - University of Lille 2 - Law and Health - University of Lille 1 Sciences and Technologies
  • Federal university of Minas Gerais (Brazil)

Funding: FAPEMIG Foundation + Nord– Pas de Calais Region / GENOSCREEN

Program: Franco-brazilian call for proposals (Nord – Pas de Calais Region and Minas Gerais State) / H2020


Bacterial Infections


PATHO-NGEN-TRACE

Development of new applications in clinical microbiology by using new NGS technologies

Partners:

  • Forschungszentrum Borstel - Leibniz-Zentrum für Medizin und Biowissenschaften – Germany
  • Westfälische Wilhelms Universität Münster – Münster - Germany
  • University of Oxford / Department of Zoology – Oxford - United Kingdom
  • Applied Maths - Sint-Martens-Latem - Belgium)
  • Piext BV – Rosmalen – The Netherlands
  • Ridom GmbH – Münster - Germany

Funding: Europe (FP VII) Grant agreement No 278864 + GENOSCREEN

Program: Patho-NGen-Trace


TUBERCULOSIS : DEVELOPMENT OF A HIGHLY SENSITIVE DETECTION KIT FOR ANTIBIOTIC RESISTANCE

Use of powerful NGS technologies to identify the mutations of the bacterium M Tuberculosis, responsible for antibiotic resistance

Partners:

  • Applied Maths - Sint-Martens-Latem – Belgium
    In the context of PATHO-NGEN-TRACE program

Funding: FP VII + GENOSCREEN

Program: Patho-NGen-Trace


ANIMAL HEALTH


MICROTYPE

Global monitoring of infectious diseases : Typing kits and databases

Partners:

  • INRA – Nouzilly - France
  • Paris-Sud University – Orsay - France

Funding: Cofunding ANR / DGA / GENOSCREEN

Program: ASTRID-maturation


ENVIRONMENT - AGRONOMY

Soil molecular microbiology


STUDY OF MICROBIAL BEHAVIOUR INVOLVED IN "NITROGEN CYCLE"

Molecular analysis of the microbial flora involved in nitrogen cycle of soils

Partners: CIDAM (Conception, engineering and development of Food and Drug), CBRV (Biomedical center for Research and Valorisation) / Auvergne University - CLERMONT-FERRAND

Funding: Cofunding GENOSCREEN / Auvergne University


BioDISSPOL

Development of microbial biomarkers for diagnosis and monitoring of polluted sites by chlorinated solvents

Partners:

  • B R G M
  • Strasbourg University

Funding: Cofunding GENOSCREEN / ADEME

Program: GESIPOL (Axis 1)


AGROFOOD

Food Microbiology

Fungal flora


FUNGI-CHEESE

Development of a complete analytical tool for fungal flora in french cheeses

Partners: INRA – Grignon - France

Funding: Cofunding GENOSCREEN / INRA

Program: Collaborative Project (INRA GENOSCREEN)

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Those projects are possible thanks to the equipments acquired in the context of the program "Investissements d'avenir" for the project ANR-10-EQPX-07