Treatments resistance prediction
Antibiotics resistance development is a major health issue because it reducts treatments possibilities in case of infection.
Some resistances are induced by genetic mutations or the acquisition of a gene by a microorganism. The detection of those mutations or those genes allows to predict the antibiotics resistance.
Genoscreen helps you to identify genetic mutations or the genes responsible for resistance to antibiotics: we define the genetic targets to study according to the suspected resistance.
ATBs which target MO membrane
- Beta-lactames : TEM, CTX, OXA, SHV, ...
- Methicilline : mecA
- Fosfomycine : fosA, fosB, fosX
- Vancomycine : VanA/VanB
ATBs which target ribosome
- Chloramphenicol : cat, ADNr50S
- Fusidic acid : fusA, fusB
- Macrolides/lincosamides/synergistines (MLS) antibiotics : ADNr 23S
- Tetracyclines : tet
- Aminoglycoside / Aminoside : rrs, rpsL
- Linezolid : ADNr 23S
ATBs which bock RNA polymerase
- Rifampicine : rpoB
ATBs which target DNA
- Quinolone : gyrA, gyrB, parC
- Isoniazide : promoteur inhA, katG
- Ethamutol : embB
- Pyrazinamide : pncA
- TMC207 : opéron ATP